... questions will be answered as teams find out whether or not they'll have a shot at the playoffs. 

The two games of the week will be the AFC South clash between the Jacksonville Jaguars and Indianapolis Colts, and the battle for NFC East supremacy between the Philadelphia Eagles and New York Giants. 

We'll witness a rookie quarterback matchup when John Skelton and the Arizona Cardinals take on Jimmy Clausen and the Carolina Panthers. 

Brett Favre might even play again!

Read on to find the key storylines around the NFL as well as the picks to each and every game. 

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